A Single-Copy Gene Encodes Kex1, a Serine Endoprotease of Pneumocystis jiroveci

A single-copy gene encodes Kex1, a serine endoprotease of Pneumocystis jiroveci.

We have cloned and characterized the kex1 gene of Pneumocystis jiroveci. Unlike the case for Pneumocystis carinii, in which the homologous PRT-1 genes are multicopy, kex1 is a single-copy gene encoding a protein homologous to fungal serine endoproteases, which localize to the Golgi apparatus. Thus, substantial biological differences can be seen among Pneumocystis species.

Pneumocystis jiroveci

Pneumocystis jiroveci, formerly known as Pneumocystis carinii, is now believed to be a fungus. P. jiroveci pneumonia is a fungal infection, the primary symptoms of which include progressive dyspnea, nonproductive cough, and low-grade fever. These patients are often profoundly hypoxemic, and chest radiographs typically show bilateral, diffuse interstitial infiltrates. While P. jiroveci pneumonia...

Co- infectious Cytomegalovirus and Pneumocystis Jiroveci Pneumonia in a Polyarteritis Nodosa Patient: A Case Report

Our report discusses a patient diagnosed with PAN since 3 years ago. He presented with fever, chills and nonproductive cough. He was a long time receiver of immunosuppressant drugs for his underlying condition. Upon examination he was febrile, had cushingoid appearance and cackles in both lungs. Lung CT scan showed opacities in right upper lobe lung and multiple bilateral nodules and ground gla...

Pneumocystis jiroveci: Epidemiology and diagnosis

Pregnancy and Asymptomatic Carriage of Pneumocystis jiroveci

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